Many of you report hypothyroidism to my office just to tell your primary health care provider that you are normal in testing. Guess what? They are correct! But so are you. However, they have not gone far enough to document what you know to be true. Your thyroid gland produces most of the thyroid gland most of the time. However, after it leaves the gland, the brain takes over and responds to environmental signals, sleep, stress, exercise, etc. This response alters the activity of enzymes that control the conversion of your thyroid hormone into its more active form, known as T3, This needs to be estimated to adequately determine your true thyroid activity. I have included a feedback diagram below this physiology.
Below is an overview of the axis of the thyroid gland:
HYPOTHALAMUS-> TRG(thyrotropin-releasing hormone - it decreases during stress) ->pituitary ---------> TSH(thyroid stimulating hormone - also decreased during periods of stress) ->Thyroid (the gland produces 4 types of thyroid hormones, T1-4- 90% of products in the form of T4, 10% T3, T2 and T1 account for <1% of the volume of output).
T3 5 times stronger than T4, Since 50-80% T4 turns into its more powerful copy, T3Transformation occurs through the activity of enzymes called DEIODINASES. They are known as D1-3 enzymes. So the brain controls the activity of the thyroid gland and why the activity of the thyroid gland decreases during stress.
D1 and D2 control the transformation of muscles and nerves. However, when stress occurs, the D3 enzyme is activated by the conversion T4-> rT3- reverseT3, Reverse T3 unable to bind to the thyroid receptor and acts as a “thyroid inhibitor”, limiting the metabolic effects of the thyroid gland.
The main stress hormone that controls all of this is CRH(hormone releasing corticotropin). It is also released by the hypothalamus in the brain. It stimulates release. adrenocorticotropic hormone(adrenocorticotropin hormone). It stimulates the adrenal glands to release adrenaline and cortisone, the main stress hormones. When CRH is released, TRG and subsequently TSH are decreasing. Think of it like this. The main function of the thyroid gland is to establish the metabolic rate and oxygen consumption in the body. When the thyroid gland decreases, fatigue, decrease in body temperature, problems with weight management, constipation, hair loss, etc. This happens under stress, because the brain thinks that it should give priority to fueling to ensure a stress response that can entail running or fighting a threat. Reducing the metabolic rate by reducing the activity of the thyroid gland will help the body maintain a sufficient amount of fuel for the stress / escape reaction. When your primary care team evaluates your thyroid, they usually measure only TSH and, perhaps T4They do not look at the rest of the chemistry.
So, when they tell you that your thyroid gland produces normal, technically they are correct, but they do not take into account the environmental influences that we all experience in our day. Not to mention the fact that there are problems with micronutrients / deficiencies in our food supply, which deny us adequate support for micronutrients, which supports the normal conversion of the thyroid gland. No rating T3 and RT3 levels, there is no confirmation of environmental / nutritional problems, and the source of hypothyroid symptoms can be missed. But here KEY MOMENT! If your brain doesn't allow you to switch to T3 and shunting to RT3 instead, he does it as compensation for your lifestyle and stressors to protect you. In many cases, trying to provide T3 to compensate for the modified transformation will not solve the problem, since the brain will see it as going against its programming. In my experience, most of the time you can get some improvement in this chemistry. However, you cannot achieve complete rebalancing without any respect for your stressors. Sorry, this is just the reality of how it works. This is a very complex chemistry that requires a more thorough assessment when symptoms of low activity are present. More and more doctors are starting to look at this in more detail. I hope this tutorial will help you learn a little about what you need to look for and ask your doctor. Unfortunately, you cannot receive a favorable response to your request. Bear in mind that there are more of us who will listen.
Hope this helps .....
