Those who know, predict the scope of gold for the Swiss pharmaceutical company Actelion in the upcoming 2012 Olympics. Their candidate, Almorexant, has been in serious training since its opening in 1998. He is expected to receive gold medals in all of the following events:
- Recipe for insomnia
- Dream booster
- Memory catalyst
- Stimulator for creativity
- Performance acceleration
- Depressant for obesity
Not a single country, nor any cure for sleep, is currently close to victory in all categories. Most of the participants left the participants sluggish, depressed, agitated, confused and complaining of muscle pain during the day.
Almorexant, already in phase III of testing and development, is likely to take home the gold in the contest for sleep in 2012. Testing is now in determining low dosage levels, the effects of increasingly higher dosage levels and side effects compared to the commonly used sleep medications, Amorexant, was discovered and developed by the Swiss pharmaceutical company Actelion. Imagine the global market for drugs that will help insomnia victims, which will improve sleep REM and, therefore, improve your dream state, which will be the catalyst for improved memory consolidation, which will stimulate your creativity by reorganizing memory packages, speeding up work, and suppressing the regulation of nutrition brain and therefore reduce obesity. The drug has already shown that it can improve all of the above. Orexin, a neuropeptide produced by the hypothalamus, affects the sleep cycle during sleep, as well as the regulation of nutrition or appetite. The main ingredient Almorexant acts as an orexin receptor antagonist in the brain.
It was found that the active ingredient, orexin-RA-1, when given to rats, stimulates healthy sleep and maximum efficacy in the maze tests the next morning. They surpassed all rats that were given regular sleep, offering improved memory capabilities. "Measurements of muscle tone and brain activity showed an increase in the sleep phase of sleep." The sleep phase of sleep is when the memory in the brain is rigidly connected, ” says Actelion CEO Jean Paul Clausel.
Shahrad Taheri, at the University of Bristol, believes that blocking the orexin system will reduce appetite and, consequently, reduce obesity.
Studies have shown that the orexin neurons of the brain are active during wakefulness and that they are silent during sleep. It has been proven that the orexin antagonist, orexin-RA-1, is much more effective than melatonin, benzodiazepines, opiates and histamines during brain penetration, increasing the total sleep time, REM sleep time, acceleration time before the decline, and it does not cause engine injuries, like other sleep medications.
Isaac Kobrin, MD and previous head of clinical development at Actelion, and now Chief Medical Officer of Actelion, a prisoner at Medicalnewstoday.com, testifies to the positive effect of almorexant on both REM and non-REM sleep. He believes that this leads to better results the next day than benzodiazepine drugs.
Until now, there have been no reports of adverse effects or safety issues in tests that have been completed. With more than 80 million Americans suffering from insomnia and 25 or more millions of patients with chronic insomnia, almorexant is ready to accept the gold medals expected in 2012 and become one of the ten best drugs of the future. According to Drug.com, in 2008 the most popular help for sleep, Ambien CR, was number 43, registering $ 865,719 in retail sales and a decrease of 1.2% compared with 2007. The second most popular dream, Lunesta, was No. 47, a record $ 771,019 in retail sales and an increase of 8.2% compared with 2007. For comparison, the # # prescribed # 1 drug in 2008 was Lipitor, cholesterol depression, which recorded $ 5,880,128 in retail sales, and this was a 4.6% decline from 2007. Ambien CR and Lunesta can have serious side effects such as slowness, depression, memory problems, agitation, fast heartbeat, confusion, reduced coordination and muscle pain, and more.
Almorexant, after testing and approval, will become the Olympic world champion of 2012, Wonder Drug of Dreams, and its name will become as famous on television as Michael Phelps. Millions of sleep deprived of people in the world will eventually receive the “good night” they deserve, as well as sweet dreams to improve memory, creativity and performance.
