Unlike most nutritional supplements, hundreds of well-managed research and testing have confirmed the potentially important health properties of resveratrol as a treatment for diabetes, cancer, inflammatory and autoimmune diseases, and neurological conditions. Without judging the actual efficacy or efficacy of resveratrol, it is clear that many people buy resveratrol as a prophylactic or treatment for a serious illness. If the resveratrol that these consumers buy is not a high-quality, properly made biologically active compound, it not only wastes its money, but also cannot get any benefits that resveratrol can offer to improve their condition.
The criteria below are based on actual scientific principles and accepted standards for evaluating either a functional dietary supplement, such as resveratrol. Standards can also be used in evaluating other supplements.
Ethical labeling
Many resveratrol suppliers do not distinguish the exact form of resveratrol or the amount contained in their supplement. Some simply call their main ingredient "red wine complex" or "proprietary blend." Considering that red wine contains less than 1% resveratrol, it seems a bit odd that a company will use this description to designate a resveratrol product, other than a goal, to conceive the actual ingredients in the product. The proprietary blend can be anything, but it certainly consists of pure resveratrol, given the relatively high cost of quality Resveratol compared to other possible ingredients.
Resveratrol consists of two major isomers, trans-resveratrol and cis-resveratrol. Only the trans isomer was associated with health benefits. The cis isomer actually acts to negate the effects of trans-resveratrol. If the seller does not state on the label that the product exists entirely from the trans-resveratrol form, it is highly likely that it contains either some or all of cis-resveratrol, which is an order of magnitude greater than the less economical form of resveratrol.
A size 0 capsule may contain about 500 mg of resveratrol if the base material is processed using pharmaceutical technology and equipment. This is the largest capsule of size that most people can easily swallow. Vendors who use large capsules do this to compensate for the fact that they simply stuff the raw extract into a capsule, without wasting time and money on cleaning and granulating the resveratrol extract. The larger size of the capsule also allows the use of various fillers and chemicals such as silicon, magnesium stalk, cellulose, and other additives. The best quality resveratrol preparations are contained in a capsule of size 0 and do not contain any additives or excipients. There is no reason why you should consume sand and other inert ingredients in your application simply because your supplier may not be concerned about using more complex processing and filling technologies.
Is red wine the best source of resveratrol?
Although much of the news about resveratrol mentions red wine grapes as a source, grapes are not a practical source of resveratrol for two important reasons. The first grape is exposed to a wide range of toxic chemicals during cultivation. Fungicides, pesticides, chemical fertilizers and many other chemicals are sprayed directly onto grapes. Since resveratrol comes from the skin, it is very difficult to eliminate contamination in the resveratrol concentrate. The second reason why grapes are not a good source of resveratrol is that it is not possible to obtain a highly effective supplement using grape extract. The concentration of resveratrol in grape skins is too low. That is why in all animal and tissue studies on the benefits of resveratrol for health, the source of resveratrol was the plant of giant bast that grows without fertilizers or agricultural chemicals in the wild.
Capsules and Packaging
The capsules themselves should be all vegetables, such as Pfizer Vcaps, and not transparent gelatin, which is made from animal product. Not only is all vegetable capsules healthier to consume than an animal, but it is designed to better regulate the release of active ingredients into the digestive tract when taken orally. What is the use of a natural supplement if the capsule is derived from collagen inside animals? skin and bones?
Resveratrol is very susceptible to deterioration of oxidation and exposure to ultraviolet radiation. High-quality additive will be protected from oxidation in the production process through the use of technological lines filled with nitrogen. The bottle containing the additive should also use an inert gas to prevent oxidation during transport. However, as soon as the bottle is open, oxygen can enter. If active packaging technology is not used to protect against this damage, the shelf life of the product will be seriously impaired. To absorb the oxygen that enters the bottle when the capsule is removed, an oxygen absorption system is needed.
dosage
The appropriate dose of trance-resveratrol is a very controversial issue, in relation to the rhetoric of providers of resveratrol, which is. However, the science regarding dosage is relatively clear. Although doses of some of the approximately 100 mg of some studies have potentially important preventive effects, the consensus is that to achieve the threshold of effectiveness, as shown in most animal studies and in vitro, carried out to date, at least 250 mg. This is equivalent to the human equivalent dose used in the study of Dr. Sinclair and many other studies. The dose recommended by most doctors for treating an existing condition is between 1,000 and 4,000 mg. however, it is recommended to consult a doctor before taking a dose of more than 1000 mg per day. No toxicity or serious side effects were observed in several animal and human studies in which up to 5,000 mg were given daily for a long period of time. In animal studies, dosages up to the human equivalent of 30,000 mg were postponed with minor side effects.
Natural Synthetic Resveratrol
Synthetic resveratrol can be obtained using one of two methods: fermentation and chemical engineering. In the case of fermentation, yeast or bacteria are genetically modified to obtain resveratrol. Chemically modified resveratrol is constructed from a broth of compounds using organic chemistry to engineer a molecule. Both processes are fraught with potential traps. In the case of fermentation, it often happens that fragments of bacteria or DNA of yeast used to produce resveratrol are found in the finished material. This means that if you use this product, you consume a new substance, that is, a compound that has never been consumed by humans, with potentially toxic or other unknown effects. In the case of a chemically modified resveratrol product, the problem is contamination with small amounts of chemicals used to make synthetic resveratrol. On a typical HPLC graph of chemically modified resveratrol, there will almost always be bursts in the diagram of what is called the “unknowns”. These trace chemicals are primary compound products that are identified and intended or are intended to be non-toxic. In addition, naturally, extracted resveratrol from a polygonal cuspidum plant is not known to be toxic and effective. None of the properties have been tested for certain with respect to synthetic resveratrol. There is only one reason why some suppliers use synthetic resveratrol instead of natural resveratrol from polygonal cuspidatum. The reason is the much lower cost of synthetic resveratrol. If the supplier does not distinguish which type of resveratrol is contained in its products, you can assume that this is a synthetic grade.
Quercetin or not quercetin?
Quercetin is a powerful antioxidant, but it cannot be combined with resveratrol or even taken for at least 8 hours after taking resveratrol. The reason that was only recently discovered is that quercetin blocks the metabolites of resveratrol by penetrating your bloodstream. Quercetin also lowers the regulation of sirtuins, exactly the opposite effect of resveratol. Until a few years ago, adding quercetin was supposed to be a good thing, because the importance of the metabolites was not understood. At that time, it was assumed that the metabolites are not responsible for the metabolic and epigenetic effects of resveratrol. Based on several highly regarded studies, we now know that it is very likely that the positive effects of resveratrol actually come mainly from these metabolites, and not from free resveratrol. These metabolites are biologically active decomposition products of resveratrol by the liver and endothelial cells lining the small intestine. By blocking these sulfates and glucorites, quercetin interferes with the ability of resveratrol to activate sirtuins, in particular SirT2, the so-called anti-aging gene, and blocks other signaling pathways through which resveratrol works and which are responsible for many of the desirable health effects of resveratrol. Moreover, the half-life of metabolites is several hours, when the half-life of free resveratrol is only about 12 minutes. In 2009, a study of the effects of resveratrol on the induction of hemoglobin cell formation in Thalasemmia patients in the blood revealed that quercetin completely blocks the ability of resveratrol to create new red blood cells. Quercetin also reversed the anti-inflammatory property of resveratol in an informal study of the palliative effect of resveratol on arthritis. There is no scientific basis for adding quercetin in addition to resveratol. If you want to take quercetin, it is easily available as an inexpensive supplement that can be taken on its own.
Powers of your supplier
Media coverage of research demonstrating the potential benefits of resveratrol has attracted new and clearly disreputable resveratrol sellers to the market. These companies have no experience in the production of food products or health supplements, researchers, laboratories or other technical resources, quality control standards have not been established, and there is no history with which to judge their reliability and integrity. Many of these companies use the form of the word resveratrol in their names and only sell through the website. Lawyers for Dr. Mehmet Oz and Oprah Winfrey recently filed a federal lawsuit against more than 50 of these companies for illegally using their trademarks and falsely claiming their products were approved by these well-known personalities.
Your resveratrol supplier should be a manufacturer, not just a resveratrol reseller from unknown sources, it should have a history of at least ten years, preferably more, ethical business operations. It must offer a range of products not only of one or two correctly identical products. His products should have passed the recently updated Consumer Lab consumer brand assessment, and her website should provide easy ways to contact the company if you have any questions, complaints or a request for a refund. If the company offers a monthly program of regular orders, you should be offered clear and convenient ways to cancel your subscription. If company products are not available in brick and mortar stores such as GNC, the Vitamin Shop and other reputable stocks, this should probably be avoided. Anyone can sell a product over the Internet, but in order for one of the products accepted at major Health and Supplement stores to require liability insurance, thorough product testing. quality and validation of the company and its directors.
The gold standard for the manufacturer lies in the fact that its products have received wide recognition from the medical and research communities. Resveratrol, used in human trials in institutions such as the Albert Einstein Medical School and NIH, is the cleanest and most thoroughly tested supplement available to the general public.
